6090. Methyl Isopropyl Ketone

Nomenclature

CAS number: 563-80-4
3-Methyl-2-butanone; 2-acetylpropane; isopropyl methyl ketone.
C5H10O; mol wt 86.13.
C 69.72%, H 11.70%, O 18.58%.

Description and references

Prepn: E. Frankland, B. F. Duppa, Ann. 138, 328 (1866). Large scale prepn: T. W. Mears et al., J. Res. Natl. Bur. Stand. 44, 299 (1950). Miscibility profile: W. M. Jackson, J. S. Drury, Ind. Eng. Chem. 51, 1491 (1959). Thermodynamic properties: J. L. Hales et al., Trans. Faraday Soc. 63, 1876 (1967). Acute toxicity: H. Tanii et al., Toxicol. Lett. 30, 13 (1986).

Chemical structure

Properties

Colorless, flammable liquid with an acetone-like odor. bp760 94.2°. fp 94.4°. d20 0.8100; d25 0.8061. nD20 1.3887; nD25 1.3861. Log P (n-octanol/water): 0.56. LD50 orally in male mice: 29.86 mmol/kg (Tanii).

Caution

Potential symptoms of overexposure are irritation of eyes, skin, mucous membranes, respiratory system; cough. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 212; Patty's Industrial Hygiene and Toxicology vol 2C, G. D. Clayton, F. E. Clayton, Eds. (Wiley-Interscience, New York, 4th ed., 1994) pp 1776-1779.

Use

Solvent.