6115. 5-Methylpyrazole-3-carboxylic Acid

Nomenclature

CAS number: 402-61-9
C5H6N2O2; mol wt 126.11.
C 47.62%, H 4.80%, N 22.21%, O 25.37%.

Description and references

Prepn: Knorr, MacDonald, Ann. 279, 219 (1894); Lehninger, J. Am. Chem. Soc. 64, 2507 (1942). Hypoglycemic metabolite of 3,5-dimethylpyrazole: Smith et al., J. Med. Chem. 8, 350 (1965).

Chemical structure

Properties

Crystals from water, mp 236-237°.

Derivative

Methyl ester.
C6H8N2O2; mol wt 140.14.
C 51.42%, H 5.75%, N 19.99%, O 22.83%.

Properties

Crystals, mp 75-78°.

Derivative

Ethyl ester.
C7H10N2O2; mol wt 154.17.
C 54.53%, H 6.54%, N 18.17%, O 20.76%.

Properties

Crystals, mp 83°.

Caution

A powerful hypoglycemic agent in rats (characteristic of pyrazoles).