6144. Metocurine Iodide
Nomenclature
CAS number: 7601-55-0
6,6′,7′,12′-Tetramethoxy-2,2,2′,2′-tetramethyltubocuraranium
diiodide; (+)-O,O′-dimethylchondrocurarine diiodide; d-tubocurarine iodide dimethyl ether; dimethyl tubocurarine iodide; tubocurarine dimethyl ether iodide; Metubine Iodide (Lilly). C40H48I2N2O6; mol wt 906.63.
C 52.99%, H 5.34%, I 27.99%, N 3.09%, O 10.59%.
Description and references
Prepd by methylation of d-tubocurarine with methyl iodide.
Properties
Crystals, dec 257-267°. [α]D22 +148 to +158° (c = 0.25). uv max: 280 nm. (E1%1cm 74). Slightly soluble in water (about 300 mg/100 ml), in dil HCl, in dil NaOH. Very slightly sol in alcohol; practically insol in benzene, chloroform, ether.Derivative
Trihydrate.Properties
Large prisms from water, appreciably sol in methanol.Therapeutic Category
Neuromuscular blocking agent.
Keywords
Neuromuscular Blocking Agent; Nondepolarizing Agents