6145. Metofenazate

Nomenclature

CAS number: 388-51-2
3,4,5-Trimethoxybenzoic acid 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester; 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazinyl]ethyl 3,4,5-trimethoxybenzoate; N-[β-(3,4,5-trimethoxybenzoyloxy)ethyl]-N′-[γ-(3-chloro-10-phenothiazinyl)propyl]piperazine; methophenazine; perphenazine 3,4,5-trimethoxybenzoate.
C31H36ClN3O5S; mol wt 598.15.
C 62.25%, H 6.07%, Cl 5.93%, N 7.03%, O 13.37%, S 5.36%.

Description and references

Prepn: Magy. Kem. Lapja 17, 169 (1962), C.A. 57, 11314d (1962); Toldy et al., Acta Chim. Acad. Sci. Hung. 42, 351 (1964).

Chemical structure

Properties

Crystals from ethanol, mp 102-107°.

Derivative

Difumarate.

Nomenclature

CAS number: 522-23-6
Frenolon (EGYT).
C31H36ClN3O5S.2C4H4O4; mol wt 830.30.
C 56.42%, H 5.34%, Cl 4.27%, N 5.06%, O 25.05%, S 3.86%.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines