6159. Metyrapone

Nomenclature

CAS number: 54-36-4
2-Methyl-1,2-di-3-pyridyl-1-propanone; 2-methyl-1,2-bis(3-pyridyl)-1-propanone; methopyrapone; mepyrapone; metopyrone; methbipyranone; Su-4885; Metopiron(e) (Novartis).
C14H14N2O; mol wt 226.27.
C 74.31%, H 6.24%, N 12.38%, O 7.07%.

Description and references

Prepn: Chart et al., Experientia 14, 151 (1958); W. L. Bencze, M. J. Allen, J. Am. Chem. Soc. 81, 4015 (1959); eidem, US 2966493 (1960 to Ciba).

Chemical structure

Properties

Crystals from ether and pentane, mp 50-51°.

Therapeutic Category

Diagnostic aid (pituitary function).

Keywords

Diagnostic Aid