6197. Milrinone

Nomenclature

CAS number: 78415-72-2
1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,2-dihydro-6-methyl-2-oxo-5-(4-pyridinyl)nicotinonitrile; Win-47203; Corotrope (Sanofi-Synthelabo); Milrila (Yamanouchi).
C12H9N3O; mol wt 211.22.
C 68.24%, H 4.29%, N 19.89%, O 7.57%.

Description and references

Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Prepn: G. Y. Lesher et al., BE 886336; G. Y. Lesher, R. E. Philion, US 4313951 (1981, 1982 both to Sterling). Improved process: B. Singh, US 4413127 (1983 to Sterling); idem, Heterocycles 23, 1479 (1985). Pharmacological profile: A. A. Alousi et al., J. Cardiovasc. Pharmacol. 5, 792, 804 (1983). HPLC determn in body fluids: J. Edelson et al., J. Chromatogr. 276, 456 (1983). Clinical studies in congestive heart failure: C. S. Maskin et al., Circulation 67, 1065 (1983); L. S. Sinoway et al., J. Am. Coll. Cardiol. 2, 327 (1983); D. S. Baim et al., N. Engl. J. Med. 309, 748 (1983).

Chemical structure

Properties

Crystals from DMF + water or from ethanol, mp >300°.

Derivative

Lactate.

Nomenclature

CAS number: 100286-97-3
Primacor (Sanofi-Synthelabo).
C12H9N3O.xC3H6O3.

Therapeutic Category

Cardiotonic.

Keywords

Cardiotonic