6196. Miloxacin

Nomenclature

CAS number: 37065-29-5
5,8-Dihydro-5-methoxy-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid; 6,7-methylenedioxy-1-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; antibiotic AB 206; AB-206; Fuldazin (Sumitomo).
C12H9NO6; mol wt 263.20.
C 54.76%, H 3.45%, N 5.32%, O 36.47%.

Description and references

Quinolone antibacterial; analog of oxolinic acid, q.v. Prepn: T. Nakagome et al., DE 2134451; eidem, US 3799930 (1972, 1974 both to Sumitomo). Mode of action: T. Nagate et al., Antimicrob. Agents Chemother. 17, 763 (1980). Series of articles on antibacterial activity, absorption and excretion in animals, determn of metabolites by HPLC: ibid. 18, 37-49 (1980). Reproduction studies in rats: T. Yamada et al., Oyo Yakuri 19, 651, 815, 833 (1980), C.A. 93, 197897x, 215570s, 215571t (1980).

Chemical structure

Properties

Colorless prisms from DMF, mp 264° (dec).

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Quinolones and Analogs