6200. Minaprine

Nomenclature

CAS number: 25905-77-5
N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine; 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine.
C17H22N4O; mol wt 298.38.
C 68.43%, H 7.43%, N 18.78%, O 5.36%.

Description and references

Prepn: H. Laborit, DE 2229215; idem, US 4169158 (1973, 1979 to Centre Etudes Exper. Clin. Physio-Biologie); C.-G. Wermuth, A. Exinger, Agressologie 13, 285 (1972). Pharmacology: H. Laborit et al., ibid. 291. Metabolism of 14C-minaprine: A. G. Rico et al., J. Pharmacol. 9, 170 (1978). Pharmacokinetics: J. P. Jeanniot et al., ibid. 169. Clinical evaluation: A. Garcia-Maffla, M. H. de Garcia, Pharmatherapeutica 2, 265 (1979). Pharmacological evaluation in depression: K. Bizière et al., Arzneim.-Forsch. 32, 824 (1982). Toxicologic study: A. G. Mazure et al., Agressologie 13, 319 (1972).

Chemical structure

Properties

Fine buff-colored needles from isopropanol, mp 122°. Insol in water. Slightly sol in cold ethanol, sol in hot ethanol, chloroform.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 25953-17-7
Agr-1240; CB-30038; Brantur (Dong-A); Cantor (Sanofi Winthrop).
C17H22N4O.2HCl; mol wt 371.30.
C 54.99%, H 6.52%, N 15.09%, O 4.31%, Cl 19.10%.

Properties

Crystals from abs ethanol, mp 182°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant