6220. Mivazerol

Nomenclature

CAS number: 125472-02-8
2-Hydroxy-3-(1H-imidazol-4-ylmethyl)benzamide; α-imidazol-4-yl-2,3-cresotamide.
C11H11N3O2; mol wt 217.22.
C 60.82%, H 5.10%, N 19.34%, O 14.73%.

Description and references

α2-Adrenergic agonist. Prepn: E. Cossement et al., EP 341231; eidem, US 4923865 (1989, 1990 both to UCB); idem et al., J. Pharm. Belg. 49, 206 (1994). Specificity for α2 adrenoceptors and binding studies: M. Noyer et al., Neurochem. Int. 24, 221 (1994). Clinical trial to improve perioperative hemodynamic stability: D. T. Mangano et al., Anesthesiology 86, 346 (1997). Mode of action study: M. Guyaux et al., Acta Anaesthesiol. Scand. 42, 238 (1998).

Chemical structure

Properties

mp 197.6°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 127170-73-4
UCB-22073.
C11H11N3O2.HCl; mol wt 253.68.
C 52.08%, H 4.77%, N 16.56%, O 12.61%, Cl 13.98%.

Properties

mp 287.8°. LD50 i.p. in mice: 760 mg/kg (Cossement).

Therapeutic Category

To reduce cardiac complications of surgery.

Keywords

α-Adrenergic Agonist