Description and references

Cholesterol solvent used to dissolve gallstones by direct biliary infusion. Semisynthetic mixture of mono- and di-glycerides of octanoic and decanoic acids of which glycerol 1-octanoate is the major component. Description of prepn from coconut oil and use in treatment of gallstones: V. K. Babayan, US 4205086 (1980 to Stokeley-Van Camp). Physical properties and clinical application: J. L. Thistle et al., Gastroenterology 78, 1016 (1980). Factors affecting cholesterol dissolution rate: J. B. Bogardus, J. Pharm. Sci. 73, 906 (1984). Clinical trial: K. R. Palmer, A. F. Hofmann, Gut 27, 196 (1986). Reviews of cholelitholytic agents: G. D. Bell, Pharmacol. Ther. 23, 79-108 (1983); R. J. Fitzgibbons et al., Surg. Annu. 21, 237-262 (1989).

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