6267. Morazone

Nomenclature

CAS number: 6536-18-1
1,2-Dihydro-1,5-dimethyl-4-[(3-methyl-2-phenyl-4-morpholinyl)methyl]-2-phenyl-3H-pyrazol-3-one; 4-[(3-methyl-2-phenylmorpholino)methyl]antipyrine; 1-phenyl-2,3-dimethyl-4-(2′-phenyl-3′-methylmorpholinomethyl)-5-pyrazolone; R-445.
C23H27N3O2; mol wt 377.48.
C 73.18%, H 7.21%, N 11.13%, O 8.48%.

Description and references

Prepn: Hengen et al., Arzneim.-Forsch. 8, 421 (1958); Siemer, Doppstadt, US 2943022; US 3005818 (1960, 1961 both to Ravensberg Chem.). Metabolism: Cartoni et al., J. Chromatogr. 84, 419 (1973).

Chemical structure

Properties

Crystals, mp 149-150°. Freely sol in chloroform; sol in methanol, acetone; slightly sol in ether.

Derivative

Hydrochloride.

Nomenclature

CAS number: 50321-35-2
C23H27N3O2.HCl; mol wt 413.94.
C 66.74%, H 6.82%, N 10.15%, O 7.73%, Cl 8.56%.

Properties

Crystals from methanol + acetone, mp 171-172° (dec). Sol in water.

Therapeutic Category

Analgesic; anti-inflammatory; antipyretic.