6289. Moxestrol

Nomenclature

CAS number: 34816-55-2
(11β,17α)-11-Methoxy-19-nor-17-pregna-1,3,5(10)-trien-20-yne-3,17-diol; 3,17-dihydroxy-11β-methoxy-19-nor-17α-pregna-1,3,5-trien-20-yne; 17α-ethynyl-11β-methoxyestra-1,3,5(10)-triene-3,17β-diol; 11β-methoxy-17α-ethynyl-Δ1,3,5(10)-estratriene-3,17β-diol; 11β-methoxy-17α-ethynylestradiol; R-2858; Surestryl (Roussel Diamant).
C21H26O3; mol wt 326.43.
C 77.27%, H 8.03%, O 14.70%.

Description and references

Prepn: Bertin, Pierdet, ZA 6703381; eidem, US 3579545; FR M6182, C.A. 72, 90739m (1970) (1968, 1971, 1968 all to Roussel-UCLAF); Azadian-Boulanger, Bertin, Chim. Ther. 8, 451 (1973). Activity studies: Raynaud, Steroids 21, 249 (1973); Raynaud et al., Mol. Pharmacol. 9, 520 (1973).

Chemical structure

Properties

Crystals, mp 280°. [α]D20 +29° (c = 0.6 in ethanol). uv max (ethanol): 280 nm (E1%1cm 58.4).

Therapeutic Category

Estrogen.

Keywords

Estrogen; Steroidal