6288. Moxaverine

Nomenclature

CAS number: 10539-19-2
3-Ethyl-6,7-dimethoxy-1-(phenylmethyl)isoquinoline; 1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline.
C20H21NO2; mol wt 307.39.
C 78.15%, H 6.89%, N 4.56%, O 10.41%.

Description and references

Prepn of hydrochloride: FR 1362765 (1964 to Orgamol, SA), C.A. 62, 536f (1965). Physical properties and solution stability: E. Pawelczyk, M. Zajac, Diss. Pharm. Pharmacol. 24, 5 (1972). HPLC determn in pharmaceutical formulations: E. H. Girgis, J. Pharm. Sci. 82, 503 (1993).

Chemical structure

Properties

Crystals, mp 71-72.5°. uv max (0.1 M H2SO4): 253 nm (A1cm1% 2164).

Derivative

Hydrochloride.

Nomenclature

CAS number: 1163-37-7
Eupaverin (Merck KGaA); Eupaverina (Bracco); Kollateral (Ursapharm).
C20H21NO2.HCl; mol wt 343.85.
C 69.86%, H 6.45%, N 4.07%, O 9.31%, Cl 10.31%.

Properties

Crystals from ethanol, mp 208-210° (dec). Sol in hot water, hot alc, and many other organic solvents; very sparingly sol in cold water.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic