6293. Moxonidine

Nomenclature

CAS number: 75438-57-2
4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine; 4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine; BDF-5895; Cynt (Beiersdorf); Physiotens (Giulini).
C9H12ClN5O; mol wt 241.68.
C 44.73%, H 5.00%, Cl 14.67%, N 28.98%, O 6.62%.

Description and references

α2-Adrenoceptor agonist. Prepn: NL 7908192; W. Stenzel et al., US 4323570 (1980, 1982 both to Beiersdorf AG). Series of articles on pharmacology and binding studies: Arzneim.-Forsch. 38, 1426-1445 (1988). Pharmacokinetics: D. Trenk et al., J. Clin. Pharmacol. 27, 988 (1987); W. Kirch et al., ibid. 30, 1088 (1990). Clinical comparison with clonidine, q.v.: V. Pl"anitz, ibid. 27, 46 (1987).

Chemical structure

Properties

mp 217-219° (dec).

Derivative

Hydrochloride.

Nomenclature

CAS number: 75438-58-3

Properties

Crystals from isopropanol/ether, mp 189°.

Therapeutic Category

Antihypertensive.

Keywords

α-Adrenergic Agonist; Antihypertensive; Imidazole Derivatives