13-06253. Mofegiline [Archived]

Nomenclature

CAS number: 119386-96-8
(βE)-4-Fluoro-β-(fluoromethylene)benzenebutanamine; (E)-2-(fluoromethylene)-4-(p-fluorophenyl)butylamine; (E)-2-(4-fluorophenethyl)-3-fluoroallylamine.
C11H13F2N; mol wt 197.22.
C 66.99%, H 6.64%, F 19.27%, N 7.10%.

Description and references

Irreversible monoamine oxidase-B (MAO-B) inhibitor. Prepn: I. A. McDonald, M. G. Palfreyman, EP 295604 (1988 to Merrell Dow). GC-MS determn in plasma and urine: B. D. Dulery et al., J. Chromatogr. 571, 241 (1991). Pharmacokinetics: eidem et al., Arzneim.-Forsch. 43, 297 (1993). Metabolism: J. Dow et al., Drug Metab. Dispos. 22, 738 (1994). Clinical pharmacology: C. Hinze et al., J. Neural Transm. Suppl. 41, 371-375 (1994). Clinical evaluation in Parkinson's disease: V. V. Myllyl et al., Adv. Neurol. 60, 676 (1993).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 120635-25-8
MDL-72974A.
C11H13F2N.HCl; mol wt 233.69.
C 56.54%, H 6.04%, F 16.26%, N 5.99%, Cl 15.17%.

Properties

Colorless plates, mp 131°.

Therapeutic Category

Antiparkinsonian.

Keywords

Antiparkinsonian; Monoamine Oxidase Inhibitor

Status

This monograph has been retired and is no longer subject to revision or update.