6303. Muraglitazar

Nomenclature

CAS number: 331741-94-7
N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine; BMS-298585; Pargluva (BMS).
C29H28N2O7; mol wt 516.54.
C 67.43%, H 5.46%, N 5.42%, O 21.68%.

Description and references

Peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist. Prepn: P. T. Cheng, WO 0121602; eidem, US 6414002 (2001, 2002 both to Bristol-Myers Squibb); P. V. Devasthale et al., J. Med. Chem. 48, 2248 (2005). Review of development and therapeutic potential: D. Barlocco, Curr. Opin. Investig. Drugs 6, 427-434 (2005).

Chemical structure

Properties

Crystals from ethanol, mp 139.1-140.2°. uv max (methanol): 224, 277 nm.

Therapeutic Category

Antidiabetic.

Keywords

Antidiabetic