6347. Nadoxolol

Nomenclature

CAS number: 54063-51-3
N,3-Dihydroxy-4-(1-naphthalenyloxy)butanimidamide; 3-hydroxy-4-(1-naphthyloxy)butyramidoxime; 4-(α-naphthyloxy)-3-hydroxybutyramidoxime.
C14H16N2O3; mol wt 260.29.
C 64.60%, H 6.20%, N 10.76%, O 18.44%.

Description and references

β-Adrenergic blocker. Prepn: Lafon, DE 2132113 corresp to US 3819702 (1972, 1974 to Orsymonde). Pharmacology: Duteil et al., Therapie 28, 703 (1973). Clinical studies: Tricot et al., ibid. 721.

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 35991-93-6
LL-1530; Bradyl (Lafon).
C14H16N2O3.HCl; mol wt 296.75.
C 56.66%, H 5.77%, N 9.44%, O 16.17%, Cl 11.95%.

Properties

White crystalline powder from ethyl ether-methanol, mp 188°. Sol in water, methanol, ethanol. Insol in ethyl ether. LD50 in mice (mg/kg): 180 i.v.; 1000 orally (Lafon).

Therapeutic Category

Antiarrhythmic.

Keywords

β-Adrenergic Blocker; Antiarrhythmic