6436. Nedocromil

Nomenclature

CAS number: 69049-73-6
9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid; 4,6-dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid; FPL-59002.
C19H17NO7; mol wt 371.34.
C 61.45%, H 4.61%, N 3.77%, O 30.16%.

Description and references

Mast cell stabilizer; also modulates production of cytokines by stimulated epithelial cells. Prepn and pharmacology: H. Cairns, D. Cox, BE 866622; eidem, US 4474787 (1978, 1984 both to Fisons); H. Cairns et al., J. Med. Chem. 28, 1832 (1985). Series of articles on pharmacology, pharmacokinetics and clinical profile in allergic rhinitis: Allergy 51, Suppl. 28, 8-34 (1996). Comparative clinical trial with cromolyn sodium, q.v., in asthma: H. J. Schwartz et al., Chest 109, 945 (1996).

Chemical structure

Properties

Yellow powder, mp 298-300° (dec).

Derivative

Disodium salt.

Nomenclature

CAS number: 69049-74-7
FPL-59002KP; Halamid (Viatris); Irtan (Aventis); Rapitil (Aventis); Tilade (Aventis); Tilarin (Aventis); Tilavist (Aventis).
C19H15NNa2O7; mol wt 415.30.
C 54.95%, H 3.64%, N 3.37%, Na 11.07%, O 26.97%.

Properties

Pale yellow powder. Sol in water.

Therapeutic Category

Antiallergic; antiasthmatic.

Keywords

Antiallergic; Antiasthmatic (Nonbronchodilator)