6439. Nefiracetam

Nomenclature

CAS number: 77191-36-7
N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide; 2-(2-oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide; 2-oxo-1-pyrrolidineaceto-2′,6′-xylidide; 2-oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide; DMMPA; DM-9384; DZL-221; Translon (Daiichi).
C14H18N2O2; mol wt 246.30.
C 68.27%, H 7.37%, N 11.37%, O 12.99%.

Description and references

Cyclic deriv of γ-aminobutyric acid. Prepn: H. Betzing et al., DE 2924011; eidem, US 4341790 (1980, 1982 both to Nattermann). Cognition enhancing effects in rats: T. Sakurai et al., Jpn. J. Pharmacol. 50, 47 (1989). HPLC determn in serum and urine: Y. Fujimaki et al., J. Chromatogr. 575, 261 (1992). Clinical pharmacokinetics: eidem, Xenobiotica 23, 61 (1993). Series of articles on pharmacology and toxicology: Arzneim.-Forsch. 44, 193-259 (1994).

Chemical structure

Properties

Crystals from water, mp 153°. LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982).

Therapeutic Category

Nootropic.

Keywords

Nootropic