Parent acid of a family of amino sugars contg 9 or more carbon atoms (sialic acids or nonulosaminic acids). May be regarded as the aldol condensation product of pyruvic acid and N-acetyl-d-mannosamine. Neuraminic acid has not been isolated and characterized as such, but several N- and O-substituted derivatives are widely distributed in nature. Review: Whelan, Annu. Rep. Prog. Chem. 54, 319 (1958); A. Gottschalk, The Chemistry and Biology of Sialic Acids and Related Substances (Cambridge Univ. Press, 1960). See also Sialic Acids.