6492. Niaprazine

Nomenclature

CAS number: 27367-90-4
N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide; N-[3-[4-(p-fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide; Nopron (Carrion).
C20H25FN4O; mol wt 356.44.
C 67.39%, H 7.07%, F 5.33%, N 15.72%, O 4.49%.

Description and references

Prepn: R. Y. Mauvernay, DE 1957371 corresp to US 3712893 (1970, 1973 both to CERM). Pharmacology: P. Duchene-Marrullaz et al., Therapie 26, 1203 (1971). Psycholeptic effects in mice: J. Hache, J. Tachon, J. Pharmacol. 7, 469 (1976). Brain catecholamine depletion: P. E. Keane, M. S. Benedetti, Neuropharmacology 18, 595 (1979).

Chemical structure

Properties

Cryst from ethyl acetate, mp 131°. Photosensitive. LD50 in mice (mg/kg): 890 orally, 145 i.v. (Mauvernay).

Therapeutic Category

Sedative; hypnotic.

Keywords

Sedative/Hypnotic; Amides