6493. Nicaraven

Nomenclature

CAS number: 79455-30-4
N,N′-(1-Methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide; 1,2-bis(nicotinamido)propane; (±)-N,N′-propylenedinicotinamide; AVS; Antevas (Chugai).
C15H16N4O2; mol wt 284.31.
C 63.37%, H 5.67%, N 19.71%, O 11.25%.

Description and references

Hydroxyl radical scavenger. Prepn: T. Mori et al., EP 29602; eidem, US 4366161 (1981, 1982 both to Chugai); T. Doi et al., Synlett 1999, 1751. Effect on human platelet aggregation: T. Komiya et al., Clin. Neuropharmacol. 22, 11 (1999). Clinical trial in subarachnoid hemorrhage: T. Asano et al., J. Neurosurg. 84, 792 (1996). Review: K. K. Jain, Expert Opin. Invest. Drugs 9, 859-870 (2000).

Chemical structure

Properties

Crystals from ethyl acetate, mp 156-157°. Sol in water.

Therapeutic Category

In treatment of vasospasm following subarachnoid hemorrhage.