6494. Nicarbazin

Nomenclature

CAS number: 330-95-0
N,N′-Bis(4-nitrophenyl)urea, compd with 4,6-dimethyl-2(1H)-pyrimidinone (1:1); 4,4′-dinitrocarbanilide compd with 4,6-dimethyl-2-pyrimidinol (1:1); Nicarb (Merck & Co.); Nicoxin; Nicrazin (Merck & Co.).
C19H18N6O6; mol wt 426.38.
C 53.52%, H 4.26%, N 19.71%, O 22.51%.

Description and references

Prepn: Cuckler et al., Science 122, 244 (1955); Basso, O'Neill, US 2731382; US 2731383; US 2731384 (all 1956 to Merck & Co.). Effect on nutritional encephalopathy in chicks: I. Bartov, P. Budowski, Poult. Sci. 58, 597 (1979).

Chemical structure

Properties

Crystals, dec 265-275°. uv max (concd H2SO4): 298 nm (A1%1cm 670). Practically insol in water. Complex is slowly dec by trituration with water, or more rapidly by dil aq acids. The dry crystals are strongly electrostatic and present some dry-mixing problems.

Therapeutic Category (Veterinary)

Coccidiostat.