6530. Nifenalol

Nomenclature

CAS number: 7413-36-7
α-[[(1-Methylethyl)amino]methyl]-4-nitrobenzenemethanol; α-[(isopropylamino)methyl]-p-nitrobenzyl alcohol; 1-(4-nitrophenyl)-2-(isopropylamino)ethanol; isophenethanol; INPEA.
C11H16N2O3; mol wt 224.26.
C 58.91%, H 7.19%, N 12.49%, O 21.40%.

Description and references

β-Adrenergic blocker. Prepn: Teotino et al., Farmaco Ed. Sci. 17, 252 (1962); eidem, GB 950682 (1964 to Selvi), C.A. 60, 13184h (1964). Pharmacology: Somani, Lum, J. Pharmacol. Exp. Ther. 147, 194 (1965); Almirante et al., Farmaco Ed. Sci. 21, 637 (1966). Prepn of the optical isomers: Almirante, Murmann, J. Med. Chem. 9, 650 (1966); eidem, BE 673273 (1966 to Selvi), C.A. 66, 65278d (1967).

Chemical structure

Properties

mp 98°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 5704-60-9
Inpea (Selvi).
C11H16N2O3.HCl; mol wt 260.72.
C 50.67%, H 6.57%, N 10.74%, O 18.41%, Cl 13.60%.

Properties

mp 181°.

Therapeutic Category

Antianginal; antiarrhythmic.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic