6540. Nifurzide

Nomenclature

CAS number: 39978-42-2
5-Nitro-2-thiophenecarboxylic acid [3-(5-nitro-2-furanyl)-2-propenylidene]hydrazide; N1-(5-nitro-2-furylacrylidene)-N2-(5-nitro-2-thenoyl)hydrazine; 5-nitro-2-thiophenecarboxylic acid [3-(5-nitro-2-furyl)allylidene]hydrazide; Ricridene (Lipha).
C12H8N4O6S; mol wt 336.28.
C 42.86%, H 2.40%, N 16.66%, O 28.55%, S 9.54%.

Description and references

Bactericidal agent related to nitrofurazone, q.v. Prepn: E. Szarvasi, L. Fontaine, DE 2200375; eidem, US 3847911 (1972, 1974 both to Lipha); E. Szarvasi et al., J. Med. Chem. 16, 281 (1973). Mode of action study: A. Delsarte et al., Antimicrob. Agents Chemother. 19, 477 (1981).

Chemical structure

Properties

Yellow crystals from DMF/ether, mp 235-236°. LD50 orally in mice: 3200 mg/kg (Szarvasi, Fontaine, 1972).

Therapeutic Category

Anti-infective.

Keywords

Antiseptic/Disinfectant; Nitrofurans