6630. 5-Nitro-2-propoxyaniline

Nomenclature

CAS number: 553-79-7
5-Nitro-2-propoxybenzenamine; 2-amino-4-nitro-1-propoxybenzene; 1-propoxy-2-amino-4-nitrobenzene; P-4000; Ultrasüss.
C9H12N2O3; mol wt 196.20.
C 55.09%, H 6.16%, N 14.28%, O 24.46%.

Description and references

A substance which is 4000 times sweeter than sugar, with no bitter aftertaste. Prepn: Verkade et al., Rec. Trav. Chim. 65, 346-360 (1946); NL 6514769 (1967 to N. V. Koffie en Theehandel), C.A. 67, 108430n (1967); A. J. de Koning, J. Chem. Educ. 53, 521 (1976); J. McK. Woollard, ibid. 57, 464 (1980). Toxicity studies: Fitzhugh et al., J. Am. Pharm. Assoc. 46, 583 (1951).

Chemical structure

Properties

Orange crystals from n-propanol + petr ether. mp 47.5-48.5°. Soly in water at 20°: 136 mg/liter. Stable in boiling water and in dil acids.