6633. Nitroscanate

Nomenclature

CAS number: 19881-18-6
1-Isothiocyanato-4-(4-nitrophenoxy)benzene; isothiocyanic acid p-(p-nitrophenoxy)phenyl ester; p-(p-nitrophenoxy)phenyl isothiocyanate; 1-(4-isothiocyanatophenoxy)-4-nitrobenzene; 4-nitro-4′-isothiocyanodiphenyl ether; cantrodifene (obsolete); CGA-23654; GS-23654; Lopatol (Novartis); Skanitrol (Schering).
C13H8N2O3S; mol wt 272.28.
C 57.35%, H 2.96%, N 10.29%, O 17.63%, S 11.78%.

Description and references

Prepn: FR 1491477 (1967 to Agripat); F. Paltauf et al., US 3697555 (1972 to Ciba-Geigy); A. Martvon, K. Antos, Chem. Zvesti 23, 181 (1969). Activity in dogs: M. A. Gemmell, G. Oudemans, Res. Vet. Sci. 19, 217 (1975).

Chemical structure

Properties

Crystals, mp 107-113° (Martvon, Antos); also reported as 124-125° (Paltauf). Insol in water. Sol in organic solvents.

Therapeutic Category (Veterinary)

Anthelmintic.