6699. Norfenefrine

Nomenclature

CAS number: 536-21-0
α-(Aminomethyl)-3-hydroxybenzene methanol; α-(aminomethyl)-m-hydroxybenzyl alcohol; 1-(m-hydroxyphenyl)-2-aminoethanol; m-hydroxyphenylethanolamine; norphenylephrine.
C8H11NO2; mol wt 153.18.
C 62.73%, H 7.24%, N 9.14%, O 20.89%.

Description and references

Chem synthesis: Sachs, FR 866569 (1941), C.A. 43, 5043c (1949); Legerlotz, US 2312916 (1943 to Ciba); Credner, Neugebauer, Arzneim.-Forsch. 3, 462 (1953); Bretschneider, H"ormann, Monatsh. Chem. 84, 1021 (1953). Synthesis and resolution: D'Amico et al., Chim. Ind. (Milan) 38, 93 (1956). Biosynthesis: Hartman et al., J. Am. Chem. Soc. 77, 816 (1955). Activity studies: Gersmeyer, Albrecht, Med. Welt 1966, 657. Metabolism: Barac, C. R. Seances Soc. Biol. Ses Fil. 155, 1598 (1961).

Chemical structure

Derivative

dl-Form hydrochloride.

Nomenclature

CAS number: 15308-34-6
Coritat (Green Cross); Depot-Novadral (Diwag); Energona (Maurer); Esbuphon (Schaper & Brümmer); Molycor-R (Mepha); Novadral (Diwag); Stagural (Stada-Chemie); Tonolift (Teisan); Vingsal (Stroschein); Zondel (Grelan).
C8H11NO2.HCl; mol wt 189.64.
C 50.67%, H 6.38%, N 7.39%, O 16.87%, Cl 18.69%.

Properties

Crystals, mp 159-160°. uv max: 274 nm (E1%1cm 91.21). Freely soluble in water.

Therapeutic Category

Adrenergic.

Keywords

α-Adrenergic Agonist