6698. Norethynodrel

Nomenclature

CAS number: 68-23-5
(17α)-17-Hydroxy-19-norpregn-5(10)-en-20-yn-3-one; 17α-ethynyl-17-hydroxy-5(10)-estren-3-one; 13-methyl-17-ethynyl-17-hydroxy-1,2,3,4,6,7,8,9,11,12,13,14,16,17-tetradecahydro-15H-cyclopenta[a]phenanthren-3-one.
C20H26O2; mol wt 298.42.
C 80.50%, H 8.78%, O 10.72%.

Description and references

Prepn: Colton, US 2691028, US 2725389 (1954, 1955 to Searle). Metabolism studies in mice: Freudenthal et al., Toxicol. Appl. Pharmacol. 24, 125 (1973).

Chemical structure

Properties

Crystals from aq methanol, mp 169-170°. [α]D +108° (1% chloroform).

Derivative

Mixture with mestranol.

Nomenclature

CAS number: 8015-30-3
Conovid E (Searle); Enavid (Searle); Enovid.

Therapeutic Category

Progestogen. In combination with estrogen as contraceptive (oral).

Keywords

Contraceptive (Oral); Progestogen