6702. Norgesterone

Nomenclature

CAS number: 13563-60-5
(17α)-17-Hydroxy-19-norpregna-5(10),20-dien-3-one; 17β-hydroxy-17α-vinylestr-5(10)-en-3-one; 17α-vinyl-5(10)-estren-17β-ol-3-one; norvinodrel; vinylestrenolone.
C20H28O2; mol wt 300.44.
C 79.95%, H 9.39%, O 10.65%.

Description and references

Prepn: Ruggieri, Ferrari, US 2983735 (1961 to Richter); eidem, US 3062713 (1962). Synthesis of racemic form: Hiscock, Whitehurst, J. Chem. Soc. 1965, 5772. Biological properties: Ruggieri et al., Steroids 5, 73 (1965).

Chemical structure

Properties

Crystals from diethyl ether-hexane, mp 142-143°. [α]D +161° (chloroform).

Derivative

Mixture with ethinyl estradiol.

Nomenclature

CAS number: 8064-75-3
Vestalin.

Therapeutic Category

Progestogen.

Keywords

Progestogen