6820. Olaflur
Nomenclature
CAS number: 6818-37-7
2,2′-[[3-[(2-Hydroxyethyl)octadecylamino]propyl]imino]bisethanol
dihydrofluoride; AmF 297; amine fluoride 297; N-(diethanolaminopropyl)-N-(ethanol)octadecylamine
dihydrofluoride; N,N,N′-tris(2-hydroxyethyl)-N′-octadecyl-1,3-diaminopropane
dihydrofluoride; SKF-38095; RonaCare (Merck KGaA). C27H58N2O3.2HF; mol wt 498.77.
C 65.02%, H 12.13%, N 5.62%, O 9.62%, F 7.62%.
Description and references
Anticariogenic organic amine fluoride; often used in combination with stannous fluoride or sodium fluoride, q.q.v. Reduces surface tension of saliva, forming a protective film on tooth surfaces. Prepn: H. Schmid, H. R. Mühlemann, US 3083143 (1963 to GABA). In vitro antimicrobial activity: H. M. Kay, M. Wilson, J. Periodontol. 59, 266 (1988). Adsorption and desorption to hydroxyapatite: J. Sefton et al., Biomaterials 17, 37 (1996). Clinical evaluation of caries inhibition in children: T. M. Marthaler, Br. Dent. J. 119, 153 (1965); of effects on plaque and gingivitis in adults: L. Shapira et al., J. Int. Acad. Periodontol. 4, 117 (1999); of reduction of erosion in enamel and dentine: C. Ganss et al., Caries Res. 38, 561 (2004).
