Humanized monoclonal antibody directed against human immunoglobulin E (IgE). Complexes with circulating IgE to prevent the IgE-mediated degranulation of mast cells during an allergic reaction. Prepn: L. G. Presta et al., J. Immunol. 151, 2623 (1993). Pharmacokinetics and effect on circulating IgE levels in allergy patients: J. Corne et al., J. Clin. Invest. 99, 879 (1997). Clinical trial in allergic asthma: H. Milgrom et al., N. Engl. J. Med. 341, 1966 (1999); in allergic rhinitis: T. B. Casale et al., J. Am. Med. Assoc. 286, 2956 (2001). Reviews of clinical efficacy in allergic asthma: S. Holgate et al., Curr. Med. Res. Opin. 17, 233-240 (2001); G. D'Amato, Expert Opin. Biol. Ther. 3, 371-376 (2003).
Antiallergic; antiasthmatic.
Antiallergic; Antiasthmatic (Nonbronchodilator)