6861. Orazamide

Nomenclature

CAS number: 2574-78-9
1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid compd with 5-amino-1H-imidazole-4-carboxamide (1:1); 5-aminoimidazole-4-carboxamide orotate; orotic acid compd with 5(or 4)-aminoimidazole-4(or 5)-carboxamide (1:1); 4-amino-5-imidazolecarboxamide orotate; AICA orotate; Aicamin (Crinos); Aicorat (Mack, Illert.).
C9H10N6O5; mol wt 282.21.
C 38.30%, H 3.57%, N 29.78%, O 28.35%.

Description and references

Prepn: FR 1351141; Haraoka, Kamiya, US 3271398 (1964, 1966 both to Fujisawa). Pharmacology and toxicology: Tamura, Shibayama, Yakugaku Kenkyu 35, 94 (1963), C.A. 64, 2652h (1966); Hashimoto, J. Vitaminol. 13, 9, 19 (1967).

Chemical structure

Derivative

Dihydrate.

Properties

Crystals, dec 284-285°. LD50 in mice (g/kg): 0.6 i.p.; >4.0 orally (Tamura, Shibayama).

Therapeutic Category

Hepatoprotectant.

Keywords

Hepatoprotectant