Description and references

Mixture of ferulic acid esters of sterols (campestrol, stigmasterol, β-sitosterol) and triterpene alcohols (cycloartanol, cycloartenol, 24-methylenecycloartanol, cyclobranol) extracted from rice bran, corn and barley oils. Isoln from rice bran oil: R. Kaneko, T. Tsuchiya, J. Chem. Soc. Jpn. Ind. Chem. Sect. 57, 526 (1954); T. Tsuchiya et al., JP 56 7182 (1956 to Agcy Ind. Sci. Technol.), C.A. 52, 15848b (1958); eidem, JP 57 4895 (1957 to Bureau Ind. Technics), C.A. 52, 5758i (1958); from corn oil: T. Tsuchiya, O. Okubo, JP 60 2945 (1960 to Bureau Ind. Technics), C.A. 54, 25609g (1960). Extraction from rice bran, corn and barley oils and purification: T. Yamamoto, DE 1301002 (1969 to Toyo Koatsu), C.A. 71, 128704r (1969). Separation of 3 major components designated oryzanols A, B and C: M. Shimizu et al., Chem. Pharm. Bull. 5, 36 (1957). Structure of A: G. Ohta, M. Shimizu, ibid. 40; of C: eidem, ibid. 6, 325 (1958); G. Ohta, ibid. 8, 5, 9 (1960). Oryzanol B was subsequently found to be a mixture of A and C: M. Shimizu, G. Ohta, ibid. 108. Separation and properties of the seven components of γ-oryzanol: T. Endo et al., Yukagaku 17, 344 (1968), C.A. 69, 37319m (1968); eidem, ibid. 18, 63 (1969), C.A. 70, 89042f (1969). General pharmacology: Y. Yamaji et al., Oyo Yakuri 25, 947 (1983), C.A. 99, 151730h (1983). Antioxidant activity in cytochrome model systems: K. Tajima et al., Biochem. Biophys. Res. Commun. 115, 1002 (1983). Effect on lipid metabolism in rats: M. Shinomiya, Tohoku J. Exp. Med. 141, 191 (1983). Antiulcerative effect on gastric lesions in mice: Y. Ichimaru et al., Nippon Yakurigaku Zasshi 84, 537 (1984), C.A. 102, 55922g (1985). Clinical evaluation in chronic gastritis: T. Arai, Kitakanto Igaku 30, 71, 85 (1980); in hyperlipidemia: G. Yoshino et al., Curr. Ther. Res. 45, 543 (1989).

Properties

Derivative

Derivative