6887. Osalmid

Nomenclature

CAS number: 526-18-1
2-Hydroxy-N-(4-hydroxyphenyl)benzamide; 4′-hydroxysalicylanilide; N-(p-hydroxyphenyl)salicylamide; N-salicoylaminophenol; oksafenamide; oxaphenamide; Driol (Sanofi); Jestmin (Kyowa); Kanochol (Taiyo); Saryuurin (Nippon Shoji); Yoshicol (Yoshitomi).
C13H11NO3; mol wt 229.23.
C 68.11%, H 4.84%, N 6.11%, O 20.94%.

Description and references

Prepn: Weizmann et al., J. Org. Chem. 13, 796 (1948). Description: Subsidia Med. 8, 103 (1956). HPLC determn in plasma: T. Sadanaga et al., J. Chromatogr. 223, 243 (1981).

Chemical structure

Properties

Crystals, mp 179°. Practically insol in cold water, acetic acid. Slightly sol in warm water, benzene, toluene. Freely sol in methanol, ethanol, ether, acetone.

Derivative

Diacetate.
C17H15NO5; mol wt 313.30.
C 65.17%, H 4.83%, N 4.47%, O 25.53%.

Properties

Needles from alcohol, mp 151°.

Therapeutic Category

Choleretic.

Keywords

Choleretic