6888. Osaterone

Nomenclature

CAS number: 105149-04-0
6-Chloro-17-hydroxy-2-oxapregna-4,6-diene-3,20-dione.
C20H25ClO4; mol wt 364.86.
C 65.84%, H 6.91%, Cl 9.72%, O 17.54%.

Description and references

Androgen receptor antagonist. Prepn: K. Shibata et al., EP 193871; eidem, US 4785103 (1986, 1988 both to Teikoku Hormone); K. Shibata et al., Chem. Pharm. Bull. 40, 935 (1992). Pharmacology: M. Murakoshi et al., Acta Pathol. Jpn. 42, 151 (1992); T. Ichikawa et al., Endocr. J. 40, 425 (1993); M. Murakoshi et al., ibid. 479.

Chemical structure

Properties

Colorless prisms from acetone/hexane, mp 218-221°.

Derivative

Acetate ester.

Nomenclature

CAS number: 105149-00-6
2-Oxachlormadinone acetate; TZP-4238.
C22H27ClO5; mol wt 406.90.
C 64.94%, H 6.69%, Cl 8.71%, O 19.66%.

Properties

Colorless prisms from acetone/hexane, mp 253-255°.

Therapeutic Category

Treatment of benign prostatic hypertrophy; antiandrogen.

Keywords

Antiandrogen; Antiprostatic Hypertrophy