6934. Oxetorone

Nomenclature

CAS number: 26020-55-3
3-Benzofuro[3,2-c][1]benzoxepin-6(12H)-ylidene-N,N-dimethyl-1-propanamine; N,N-dimethylbenzofuro[3,2-c][1]benzoxepin-Δ6(12H),γ-propylamine; 6-(3-dimethylaminopropylidene)benzo[b]benzofurano[2,3-e]oxepine.
C21H21NO2; mol wt 319.40.
C 78.97%, H 6.63%, N 4.39%, O 10.02%.

Description and references

Novel serotonin and histamine antagonist with antimigraine activity. Prepn: F. Binon, M. Descamps, DE 1963205 corresp to US 3651051 (1970, 1972 both to Labaz). Metabolism in vitro: E. Rossi et al., J. Chromatogr. 152, 228 (1978). Use in treatment of migraine: J. J. Dufresne, Praxis 67, 1148 (1978); J. Florence, ibid. 1323; in chronic headache: U. Thoden, Therapiewoche 30, 492 (1980).

Chemical structure

Derivative

Fumarate.

Nomenclature

CAS number: 34522-46-8
L-6257; Nocertone (Labaz); Oxedix (Labaz).
C25H25NO6; mol wt 435.47.
C 68.95%, H 5.79%, N 3.22%, O 22.04%.

Properties

Cryst from isopropanol, mp 160°.

Therapeutic Category

Analgesic (specific in migraine).

Keywords

Antimigraine; Serotonin Receptor Antagonist