Description and references

Bisphosphonate similar to etidronic acid, q.v. Prepn: O. T. Quimby, FR 1506840; idem, US 3422137 (1967, 1969 both to Procter & Gamble); of sodium salt: idem et al., J. Org. Chem. 32, 4111 (1967). Prepn of ^99mTc-complex: J. A. Bevan, EP 7676; idem, US 4247534 (1980, 1981 both to Procter & Gamble); and osteotropic properties: T. S. T. Wang et al., J. Nucl. Med. 21, 767 (1980). Biodistribution: J. A. Bevan et al., ibid. 961. Radiochemical purity: W. Majewski et al., J. Nucl. Med. Technol. 11, 23 (1983). Clinical evaluation as skeletal imaging agent: P. A. Domstad et al., Radiology 136, 209 (1980). Diagnostic use in Paget's disease: A. Evans et al., Eur. J. Nucl. Med. 18, 757 (1991); for localization of bone metastases: F. Tenenbaum et al., ibid. 20, 1168 (1993).

Derivative

Derivative