6943. Oxitropium Bromide

Nomenclature

CAS number: 30286-75-0
[7(S)-(1α,2β,4β,5α,7β)]-9-Ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide; (8r)-6β,7β-epoxy-8-ethyl-3α-hydroxy-1αH,5αH-tropanium bromide (-)-tropate; (-)-N-ethylnorscopolamine methobromide; Ba-253; Ba-253-BR-L; Oxivent (Boehringer, Ing.); Tersigat (Boehringer, Ing.); Ventilat (Thomae).
C19H26BrNO4; mol wt 412.32.
C 55.35%, H 6.36%, Br 19.38%, N 3.40%, O 15.52%.

Description and references

Anticholinergic bronchodilating agent. Prepn: K. Zeile et al., US 3472861 (1969 to Boehringer, Ing.). Comparison with fenoterol, q.v.: D. Nolte, Respiration 36, 32 (1978); with ipratropium bromide, q.v.: J. Lulling et al., ibid. 42, 188 (1981). Efficacy in bronchial asthma: H. M. Beumer et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 168 (1981); in exercise-induced asthma: K. Larsson, Respiration 43, 57 (1982).

Chemical structure

Properties

Crystals, mp 203-204° (dec). [α]D21 -25° (c = 2.0 in water).

Therapeutic Category

Bronchodilator.

Keywords

Bronchodilator; Quaternary Ammonium Compounds; Antimuscarinic