6944. Oxolamine

Nomenclature

CAS number: 959-14-8
N,N-Diethyl-3-phenyl-1,2,4-oxadiazole-5-ethanamine; 5-(2-diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole; 3-phenyl-5-(β-diethylaminoethyl)-1,2,4-oxadiazole; 683-M.
C14H19N3O; mol wt 245.32.
C 68.54%, H 7.81%, N 17.13%, O 6.52%.

Description and references

Prepn: DE 1097998 (1961 to Angelini Francesco), C.A. 56, 11598h (1962). Teratogenicity studies of oxolamine citrate: L. Nilsson, Arzneim.-Forsch. 17, 781 (1967).

Chemical structure

Properties

Liquid, bp0.4 127°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1219-20-1
C14H19N3O.HCl; mol wt 281.78.
C 59.67%, H 7.15%, N 14.91%, O 5.68%, Cl 12.58%.

Properties

Crystals, mp 153-154°.

Derivative

Citrate.

Nomenclature

CAS number: 1949-20-8
AF-438; Bredon (Organon); Broncatar (Pulitzer); Perebron (Angelini); Prilon (Cassenne); Flogobron (Intersint); Oxarmin.
C14H19N3O.C6H8O7; mol wt 437.44.
C 54.91%, H 6.22%, N 9.61%, O 29.26%.

Properties

Crystals, slightly sol in water, alcohol. uv max (aq soln): 239 nm (ε 260), 273, 283 nm.

Therapeutic Category

In inflammatory conditions of respiratory tract.

Keywords

Antitussive