7002. Pamicogrel

Nomenclature

CAS number: 101001-34-7
2-[4,5-Bis(4-methoxyphenyl)-2-thiazolyl]-1H-pyrrole-1-acetic acid ethyl ester; ethyl 2-[4,5-bis(p-methoxyphenyl)-2-thiazolyl]pyrrole-1-acetate; KB-3022; KBT-3022.
C25H24N2O4S; mol wt 448.53.
C 66.94%, H 5.39%, N 6.25%, O 14.27%, S 7.15%.

Description and references

Cyclooxygenase inhibitor. Prepn: K. Yoshino et al., EP 159677; eidem, US 4659726 (1985, 1987 both to Kanebo). HPLC determn in plasma and urine: Y. Nakada et al., Chem. Pharm. Bull. 38, 1093 (1990). Pharmacokinetics: Y. Nakada et al., Yakuzaigaku 53, 210 (1993), C.A. 120, 315100 (1993). Activity as antithrombotic: K. Yokoto et al., Jpn. J. Pharmacol. 68, 201 (1995); as platelet aggregation inhibitor: K. Yokoto et al., J. Pharm. Pharmacol. 47, 768 (1995). Evaluation of cerebral protective effects: N. Yamamoto et al., Jpn. J. Pharmacol. 69, 421 (1995); eidem, Eur. J. Pharmacol. 297, 225 (1996).

Chemical structure

Properties

Crystals from ligroin, mp 132.5-135.5°. LD50 orally in male mice: >3000 mg/kg (Yoshino).

Therapeutic Category

Antithrombotic.

Keywords

Antithrombotic