7003. Pamidronic Acid

Nomenclature

CAS number: 40391-99-9
(3-Amino-1-hydroxypropylidene)bisphosphonic acid; 3-amino-1-hydroxypropane-1,1-diphosphonic acid; ADP; AHPrBP.
C3H11NO7P2; mol wt 235.07.
C 15.33%, H 4.72%, N 5.96%, O 47.64%, P 26.35%.

Description and references

Bisphosphonate antiresorptive agent. Prepn: F. Krueger et al., DE 2130794 (1973 to Benckiser), C.A. 78, 84528z (1973); K.-H. Worms et al., Z. Anorg. Allg. Chem. 457, 214 (1979). Improved process: H. Blum, K.-H. Worms, US 4327039 (1982 to Henkel). Mechanism of action study: P. M. Boonekamp et al., Bone Miner. 1, 27 (1986). HPLC determn in serum and plasma: R. W. Sparidans et al., J. Chromatogr. B 705, 331 (1998). Clinical trial to prevent postmenopausal bone loss: B. Lees et al., Osteoporos. Int. 6, 480 (1996). Review of pharmacology and therapeutic use in resorptive bone disease: A. Fitton, D. McTavish, Drugs 41, 289-318 (1991); A. J. Coukell, A. Markham, Drugs Aging 12, 149-168 (1998); of therapeutic potential in Paget's disease: P. L. Selby, Bone 24, 57S-58S (1999).

Chemical structure

Derivative

Disodium salt.

Nomenclature

CAS number: 57248-88-1
Pamidronate disodium; GCP-23339A; Aredia (Novartis); Ostepam (Nordic); Pamifos (Vipharm); Pamisol (Mayne Pharma).
C3H9NNa2O7P2; mol wt 279.03.
C 12.91%, H 3.25%, N 5.02%, Na 16.48%, O 40.14%, P 22.20%.

Therapeutic Category

Bone resorption inhibitor.

Therapeutic Category (Veterinary)

Antidote (vitamin-D analog hypercalcemia).

Keywords

Antiosteoporotic; Antipagetic; Bone Resorption Inhibitor