7029. Paramethasone

Nomenclature

CAS number: 53-33-8
(6α,11β,16α)-6-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6α-fluoro-16α-methylprednisolone; 16α-methyl-6α-fluoroprednisolone.
C22H29FO5; mol wt 392.46.
C 67.33%, H 7.45%, F 4.84%, O 20.38%.

Description and references

Prepn: Edwards et al., J. Am. Chem. Soc. 82, 2318 (1960). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Derivative

21-Acetate.

Nomenclature

CAS number: 1597-82-6
Cortidene (Syntex Latino); Dilar (Cassenne); Dillar (Sarva-Syntex); Haldrate (Lilly); Haldrone (Lilly); Metilar (Syntex); Monocortin (Grünenthal); Paramezone (Recordati); Syntecort (Medicamenta); Stemex (Syntex).
C24H31FO6; mol wt 434.50.
C 66.34%, H 7.19%, F 4.37%, O 22.09%.

Properties

mp 228-241° (dec). [α]D +85°. uv max (ethanol): 243 nm (log ε 4.16). Sol in ethanol, acetone; slightly sol in water. LD50 i.p. in female rats: 392±23 mg/kg (Goldenthal).

Derivative

Disodium phosphate.

Nomenclature

Soludillar (Syntex).

Derivative

Mixture of 21-acetate and disodium phosphate.

Nomenclature

Triniol (Syntex).

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid