7038. Pargyline

Nomenclature

CAS number: 555-57-7
N-Methyl-N-2-propynylbenzenemethanamine; N-methyl-N-2-propynylbenzylamine; N-benzyl-N-methyl-2-propynylamine; N-methyl-N-propargylbenzylamine; MO-911; A-19120; Eudatin (Abbott); Supirdyl.
C11H13N; mol wt 159.23.
C 82.97%, H 8.23%, N 8.80%.

Description and references

Monoamine oxidase inhibitor. Prepd from propargyl bromide and benzylmethylamine: GB 906245; Martin, US 3155584 (1962 and 1964, both to Abbott). Activity as a glucuronyl transferase inducer: Yeh, Mitchell, Experientia 28, 298 (1972).

Chemical structure

Properties

Free base, bp11 96-97°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 306-07-0
Eutonyl (Abbott).
C11H13N.HCl; mol wt 195.69.
C 67.51%, H 7.21%, N 7.16%, Cl 18.12%.

Properties

Crystals from ethanol + ether, mp 154-155°. Readily sol in water. Aq solns are unstable.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Monoamine Oxidase Inhibitor