7039. Paricalcitol

Nomenclature

CAS number: 131918-61-1
(1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol; 19-nor-1α,25-dihydroxyvitamin D2; Zemplar (Abbott).
C27H44O3; mol wt 416.64.
C 77.83%, H 10.64%, O 11.52%.

Description and references

Synthetic analog of vitamin D. Prepn: H. F. DeLuca et al., EP 387077; eidem, US 5587497 (1990, 1996 both to Wisconsin Alum. Res.). Series of articles on pharmacology and clinical experience in secondary hyperparathyroidism: Am. J. Kidney Dis. 32, Suppl. 2, S40-S66 (1998). Review: M. M. Goldenberg, Clin. Ther. 21, 432-441 (1999).

Chemical structure

Therapeutic Category

Antihyperparathyroid.

Keywords

Antihyperparathyroid