7080. Pempidine

Nomenclature

CAS number: 79-55-0
1,2,2,6,6-Pentamethylpiperidine.
C10H21N; mol wt 155.28.
C 77.35%, H 13.63%, N 9.02%.

Description and references

Ganglion blocking agent. Prepn by methylation of 2,2,6,6-tetramethylpiperidine: Leonard, Hauck, J. Am. Chem. Soc. 79, 5289 (1957); Hall, ibid. 5447. Description: Spinks, Young, Nature 181, 1397 (1958); Lee et al., ibid. 1717.

Chemical structure

Properties

Liquid. pK at 30° = 11.25. Extremely basic reaction for a tertiary amine. bp760 147°. nD21 1.4550.

Derivative

p-Toluenesulfonate.
C17H19NO3S; mol wt 317.40.
C 64.33%, H 6.03%, N 4.41%, O 15.12%, S 10.10%.

Properties

Crystals from ethyl acetate + ethanol, mp 162-163°.

Derivative

Tartrate.

Nomenclature

CAS number: 546-48-5
M & B 4486; Pempidil (Farmigea); Pempiten (I.G.I.); Perolysen (M & B); Tenormal (Zeneca); Tensinol (Farmaroma); Tensoral (Diana).
C10H21N.C4H6O6; mol wt 305.37.
C 55.06%, H 8.91%, N 4.59%, O 31.44%.

Properties

Crystals, mp 160°. Sol in alcohol, moderately sol in water.

Derivative

Hydrochloride.
C10H21N.HCl; mol wt 191.74.
C 62.64%, H 11.56%, N 7.31%, Cl 18.49%.

Properties

Crystals, sol in water, alc.

Therapeutic Category

Tartrate as antihypertensive.

Keywords

Antihypertensive