7127. Pentifylline

Nomenclature

CAS number: 1028-33-7
1-Hexyl-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione; 1-hexyltheobromine; 1-hexyl-3,7-dimethylxanthine; 3,7-dimethyl-1-hexyl-1H,3H-purin-2,6-dione; SK-7; Cosaldon (HMR).
C13H20N4O2; mol wt 264.32.
C 59.07%, H 7.63%, N 21.20%, O 12.11%.

Description and references

Prepn from theobromine and hexyl halide: Eidebenz, Schuh, DE 860217 (1952 to Chem. Werke Albert); Serchi, Chimica 40, 451 (1964); Chkhikvadze et al., SU 202152 (1967), C.A. 69, 19368x (1968). Pharmacology: Cugurra, Echinard-Garin, Arch. Int. Pharmacodyn. Ther. 123, 481 (1960); Ramos et al., ibid. 153, 430 (1965); Mohler et al., Arzneim.-Forsch. 16, 1524 (1966). Metabolic studies: Mohler et al., Arch. Pharm. 299, 448 (1966).

Chemical structure

Properties

Crystals, mp 82-83°.

Use

Stabilizer of vitamin preparations: Nook, Eidebenz, DE 1810705 (1970 to Chem. Werke Albert).

Therapeutic Category

Vasodilator.

Keywords

Vasodilator (Cerebral); Vasodilator (Peripheral)