7128. Pentigetide

Nomenclature

CAS number: 62087-72-3
N2-[1-[N-(N-l-α-Aspartyl-l-seryl)-l-α-aspartyl]-l-prolyl]-l-arginine; human IgE pentapeptide; HEPP; Pentyde (Immunetech).
C22H36N8O11; mol wt 588.57.
C 44.89%, H 6.17%, N 19.04%, O 29.90%.

Description and references

Synthetic pentapeptide with antiallergic activity. Structure corresponds to amino acids 320-324 of the epsilon chain of human immunoglobulin E (IgE). Prepn: R. N. Hamburger, DE 2602443; idem, US 4171299 (1976, 1979 both to Univ. California). Inhibition of IgE-mediated immediate hypersensitivity response: idem, Science 189, 389 (1975). Stimulation of peritoneal macrophages: E. Tzehoval et al., Proc. Natl. Acad. Sci. USA 75, 3400 (1978). Mechanism of action study: R. N. Hamburger, Immunology 38, 781 (1979). Clinical evaluations in allergic rhinitis: G. A. Cohen et al., Ann. Allergy 52, 83 (1984); B. M. Prenner, ibid. 58, 332 (1987).

Chemical structure

Properties

[α]D20 -78.6° (c = 1 in water).

Therapeutic Category

Antiallergic.

Keywords

Antiallergic