7129. Pentisomide
Nomenclature
CAS number: 78833-03-1
α-[2-[Bis(1-methylethyl)amino]ethyl]-α-(2-methylpropyl)-2-pyridineacetamide; 2-[2-(diisopropylamino)ethyl]-4-methyl-2-(2-pyridyl)pentanamide; propisomide; penticainide; CM-7857; ME-3202. C19H33N3O; mol wt 319.48.
C 71.43%, H 10.41%, N 13.15%, O 5.01%.
Description and references
Sodium channel blocker; derivative of disopyramide, q.v. Prepn: H. Demarne et al., EP 27412; eidem, US 4356177 (1981, 1982 both to C. M. Industries); C. A. Bernhart et al., J. Med. Chem. 26, 451 (1983). Electrophysiological study: V. Kühlkamp et al., Int. J. Cardiol. 36, 69 (1992). HPLC determn in plasma, urine, and tissues: T. A. Plomp, M. J. H. Buijs, J. Chromatogr. 612, 123 (1993). Clinical evaluation: S. G. Priori et al., Am. J. Cardiol. 60, 1068 (1987); S. G. Mangini et al., Eur. Heart J. 12, 712 (1991). Review: S. Yuan, S. B. Olsson, Cardiovasc. Drug Rev. 11, 74-93 (1993).
Properties
White crystals from diisopropyl ether, mp 108-109°. Sol in water.Therapeutic Category
Antiarrhythmic (class I).
Keywords
Antiarrhythmic