7179. Perlapine

Nomenclature

CAS number: 1977-11-3
6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine; 6-(4-methyl-1-piperazinyl)morphanthridine; AW-14′2333; HF-2333; MP-11; Hypnodin (Takeda).
C19H21N3; mol wt 291.39.
C 78.32%, H 7.26%, N 14.42%.

Description and references

Prepn: GB 1006156; J. Schmutz, F. Hunziker, US 3389139 (1965, 1968 both to Wander); Hunziker et al., Helv. Chim. Acta 49, 1433 (1966). Pharmacology: Y. Take et al., J. Takeda Res. Lab. 29, 416 (1970); G. Stille et al., Psychopharmacologia 28, 325 (1973). Toxicology study: H. Yokotani et al., J. Takeda Res. Lab. 29, 441 (1970).

Chemical structure

Properties

Yellow, prismatic crystals from acetone-petrol ether, mp 136-138°. LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani).

Therapeutic Category

Hypnotic.

Keywords

Sedative/Hypnotic